abstract：:The separate and combined effects of successive administration of amantadine, 100 mg/kg, i.p., and chlorpromazine, 0.2 mg/kg, i.p., on motor activity and whole brain levels of certain biogenic amines and major metabolites were studied in four strains of mice. These were the albino ICR, the inbred BALB/C, C57BL/6 and t...

journal_title：Neurotoxicology

authors： Messiha FS

更新日期：1991-10-01 00:00:00

abstract：:The N-oxide of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the major metabolite found in vivo and excreted in urine after the parenteral administration of the neurotoxicant, MPTP. In mice (C57BL/6), stereotaxic injection of MPTP N-oxide (15 micrograms) into the neostriatum produced dopamine (DA) depletion s...

journal_title：Neurotoxicology

authors： Lau YS,Fung YK,Trobough KL,Cashman JR,Wilson JA

更新日期：1991-07-01 00:00:00

abstract：:Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions. However, administration of alpha-tocopherol (335 or 585 mg/kg) in combination with sodium metavanadate decreased the vanadium-sti...

journal_title：Neurotoxicology

authors： Haider SS,el-Fakhri M

更新日期：1991-04-01 00:00:00

abstract：:Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...

journal_title：Neurotoxicology

authors： Cory-Slechta DA,Pokora MJ,Widzowski DV

更新日期：1991-01-01 00:00:00

abstract：:In this study, we report initial results concerning the effects of elevated dietary trace metals upon delayed relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. Animals were assigned to a control diet as well as to diets with increased content of NiS0(4) and ZnS0(4) prior to immunization for EAE. Dur...

journal_title：Neurotoxicology

authors： Schiffer RB,Herndon RM,Eskin T

更新日期：1990-10-01 00:00:00

abstract：:A Workshop on the Qualitative and Quantitative Comparability of Human and Animal Developmental Neurotoxicity was held in Williamsburg, Va. on April 11-13, 1989. Based upon data presented at the Workshop, the degree of qualitative and quantitative comparability between data obtained from humans and experimental animals...

journal_title：Neurotoxicology

authors： Rees DC,Francis EZ,Kimmel CA

更新日期：1990-07-01 00:00:00

abstract：:The estimation of risk for health effects due to chemical exposure is important to the development of standards for regulating the manufacture, use and release of chemicals into the environment. The quantitative data used to develop risk estimates usually come from laboratory animal studies employing relatively high d...

journal_title：Neurotoxicology

authors： Kimmel CA

更新日期：1990-07-01 00:00:00

abstract：:We have recently observed that DDT and a DDT metabolite, DDOH, conjugated to a fatty acid, palmitic acid, DDOH-PA, affects muscarinic cholinergic receptors (MAChR) in the neonatal mouse brain when given to suckling mice during rapid brain growth. This early exposure of the neonatal mouse also affects the behaviour of ...

journal_title：Neurotoxicology

authors： Eriksson P,Nilsson-Håkansson L,Nordberg A,Aspberg A,Fredriksson A

更新日期：1990-07-01 00:00:00

abstract：:Young children are especially susceptible to the toxic effects of lead. Although the effects of overt lead intoxication have been well studied, critical information on the long-term effects of low level lead exposure is lacking. The results of recent clinical studies indicate that "chronic" low level lead exposure dur...

journal_title：Neurotoxicology

authors： Miller GD,Massaro TF,Massaro EJ

更新日期：1990-04-01 00:00:00

abstract：:Neurotransmitter amino acid levels were measured in select brain regions of rats and mice after chronic treatment with sublethal doses of sodium hydrosulfide (NaHS). Brainstem aspartate, glutamate, glutamine, taurine and GABA levels increased in chronically but not acutely saline-treated rats. These increases may have...

journal_title：Neurotoxicology

authors： Warenycia MW,Kombian SB,Reiffenstein RJ

更新日期：1990-04-01 00:00:00

abstract：:A device using four infra-red light photocells per cage which monitor simultaneously the motility of 120 individual rodents, was developed at our institute. The measuring interval can be chosen freely, the starting time may be set freely and the test may last several weeks. The motility of the offspring (day 35-39) of...

journal_title：Neurotoxicology

authors： Thiel R,Chahoud I,Schwabe R,Neubert D

更新日期：1989-10-01 00:00:00

abstract：:Mice who were exposed to phenobarbital prenatally (B mice) had at adulthood deficits in the hippocampal eight-arm maze, spontaneous alternations, and water maze behaviors. Morphological studies revealed neuronal losses in the hippocampus. The surviving neurons had reductions from control in the number of dendritic bra...

journal_title：Neurotoxicology

authors： Yanai J,Fares F,Gavish M,Greenfeld Z,Katz Y,Marcovici G,Pick CG,Rogel-Fuchs Y,Weizman A

更新日期：1989-10-01 00:00:00

abstract：:Electron microscopy has been used to characterize the products of the reactions of aluminum with DNA under three different conditions, one of which, pH 5 and Al (III)/DNA(P) ratio of 0.4, has been previously shown to produce reversible interstrand crosslinking in double-stranded DNA molecules. Under this condition, al...

journal_title：Neurotoxicology

authors： Karlik SJ,Chong AA,Eichhorn GL,De Boni U

更新日期：1989-07-01 00:00:00

abstract：:Neurofilament (NF) protein crosslinking has been proposed as the ultimate pathogenetic mechanism underlying the neuropathies caused by the gamma-diketones 2,5-hexanedione (HD) and 3,4-dimethyl-2,5-hexanedione (DMHD). Mammalian models have been used to investigate this hypothesis, but alternative experimental models ar...

journal_title：Neurotoxicology

authors： St Clair MB,Anthony DC,Wikstrand CJ,Graham DG

更新日期：1989-01-01 00:00:00

abstract：:Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environme...

journal_title：Neurotoxicology

authors： Seegal RF,Brosch K,Bush B,Ritz M,Shain W

更新日期：1989-01-01 00:00:00

abstract：:In normal cerebral development, language function typically becomes lateralized in the left hemisphere in most individuals. It is theorized that disturbances in the development of this cerebral asymmetry may result in language dysfunction such as dyslexia and dysphasia. Recently, it has been reported that language dis...

journal_title：Neurotoxicology

authors： Shucard DW,Shucard JL,Thomas DG

更新日期：1988-10-01 00:00:00

abstract：:An injection of trimethyltin (TMT) into adult male Wistar rats produced a transient hyperirritability and aggressive behavior. When these effects of the drug subsided, the rats were still markedly impaired in performance of a spatial memory task examined in a watermaze. Activity of neurons in the hippocampus of these ...

journal_title：Neurotoxicology

authors： Segal M

更新日期：1988-10-01 00:00:00

abstract：:The acute biocidal effects of organophosphorus pesticides are a central feature of modern agricultural chemistry, and also define the concerns of regulatory toxicology. Less well known, but more complex and idiosyncratic, is the potential for some agents to produce a delayed and progressive polyneuropathy--Organophosp...

journal_title：Neurotoxicology

authors： Cherniack MG

更新日期：1988-07-01 00:00:00

abstract：:The concentrations of 17 elements in the hair and nails of 180 Alzheimer's disease (AD) and control subjects have been determined by instrumental neutron activation analysis (INAA). Comparisons of trace element levels of properly matched AD and control groups revealed significant imbalances in the concentrations of si...

journal_title：Neurotoxicology

authors： Vance DE,Ehmann WD,Markesbery WR

更新日期：1988-07-01 00:00:00

abstract：:Simple visual reaction time was measured in a group of adult monkeys (Macaca fascicularis) dosed continuously with lead from birth onward, and in matched controls. Blood lead concentrations had been stable for 6 years at 33 micrograms/dl at the time of testing. The monkey was required to make contact with a stainless ...

journal_title：Neurotoxicology

authors： Rice DC

更新日期：1988-04-01 00:00:00

abstract：:Intracerebral injection of methylmercury (CH3Hg) into the mouse brain resulted in significant weight loss and the appearance of characteristic neurological disturbances associated with CH3Hg intoxication. Neurological effects appeared dependent upon a minimum injected dose of 16 micrograms of CH3Hg corresponding to a ...

journal_title：Neurotoxicology

authors： Fair PH,Balthrop JE,Braddon-Galloway S

更新日期：1987-07-01 00:00:00

abstract：:Chlordecone (0.1 to 10 mg) or corn oil vehicle was injected into Japanese quail eggs on day 1 of incubation. Higher doses (0.5-10 mg per egg) produced tremor and ataxia at hatching and dose-related decreases in hatchability and survivability. Doses lower than 0.25 mg per egg had no effects. Gonad weights were not affe...

journal_title：Neurotoxicology

authors： Gildersleeve RP,Tilson HA,Wiard RP,Edens FW

更新日期：1987-07-01 00:00:00

abstract：:Methylmercury has been designated a "behavioral teratogen" because of its ability to evoke abnormalities in the absence of gross morphological damage to the developing brain. Recent work indicates that exposure to doses of methylmercury associated with neurobehavioral actions causes early alterations in brain ornithin...

journal_title：Neurotoxicology

authors： Slotkin TA,Bartolome J

更新日期：1987-04-01 00:00:00

abstract：:The ubiquitous functional roles of brain catecholamines have led to the notion that in vitro neurochemical changes in these systems may predict neurotoxicity. Conversely, others have argued that the appropriate use of neurochemical methods is for testing specific hypotheses that are developed based on observed phenome...

journal_title：Neurotoxicology

authors： Mailman RB,Lewis MH

更新日期：1987-04-01 00:00:00

abstract：:Rats were anesthetized with urethane, implanted with stimulating and recording electrodes in the perforant path and dentate gyrus, and exposed to different doses of lindane. Analysis of evoked field potential responses indicated that lindane exposure resulted in consistent, dose-dependent changes. Two separable effect...

journal_title：Neurotoxicology

authors： Joy RM,Albertson TE

更新日期：1987-01-01 00:00:00

abstract：:The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous a...

journal_title：Neurotoxicology

authors： Cheney PD,Kasser RJ,Holsapple J

更新日期：1987-01-01 00:00:00

abstract：:Kainic acid (KA) was injected intraperitoneally into rats at a dose (9 mg/kg) which produced status epilepticus in approximately 50% of the animals. Rats were categorized into groups that displayed status epilepticus, partial seizures or no effect in the 4 hr following kainic acid injection. Behavioral and morphologic...

journal_title：Neurotoxicology

authors： O'Shaughnessy D,Gerber GJ

更新日期：1986-10-01 00:00:00

abstract：:Selected polychlorocycloalkane and pyrethroid insecticides were evaluated as inhibitors of gamma-aminobutyric acid (GABA)-dependent chloride flux into mouse brain vesicles. The inhibitory potencies of the polychlorocycloalkane insecticides, measured as concentrations producing 50% inhibition, spanned a 1200-fold conce...

journal_title：Neurotoxicology

authors： Bloomquist JR,Adams PM,Soderlund DM

更新日期：1986-10-01 00:00:00

abstract：:In the past six years, our research group has investigated the relationship between lead exposure and mental and behavioural development. This has been carried out through studies in children and animals. Earlier studies in children have shown that associations might be expected between environmental exposure to lead ...

journal_title：Neurotoxicology

authors： Moore MR,McIntosh MJ,Bushnell IW

更新日期：1986-07-01 00:00:00

abstract：:Pertussis is a unique disease in which the harmful effects are mediated by an exotoxin that effects stimulation of the adrenergic system which is neuronally controlled. The interdependence of the growth of bacteria and toxin production, and the local colonization of the bacteria that precedes the clinical symptom of t...

journal_title：Neurotoxicology

authors： Pittman M

更新日期：1986-07-01 00:00:00

abstract：:In a series of experiments, prenatal administration of phenytoin to rats at non-embryotoxic and non-teratogenic doses produced offspring exhibiting large and enduring abnormalities in behavior. Plasma drug concentrations on the last day of exposure in the dams were within the human therapeutic range for anticonvulsant...

journal_title：Neurotoxicology

authors： Vorhees CV

更新日期：1986-07-01 00:00:00

abstract：:In summary, relatively few solvents have been examined for developmental neurotoxicology. Although most of the studies have not been replicated, the majority of the solvents tested have produced significant differences from controls. Many used inhalation, which is often the most likely route of occupational or environ...

journal_title：Neurotoxicology

authors： Nelson BK

更新日期：1986-07-01 00:00:00

abstract：:The mechanism of action of acrylamide (ACR) in producing a central-peripheral distal axonopathy is unknown. We have tested the hypothesis that ACR inhibition of enzymes of oxidative metabolism is responsible for compromise of the energy supply, thereby producing the neuropathy. A single 50 mg/kg i.p. dose of ACR resul...

journal_title：Neurotoxicology

authors： Sickles DW,Goldstein BD

更新日期：1986-04-01 00:00:00

abstract：:Neural cell cultures were used to investigate the effects of acute and chronic ethanol exposure on electric membrane properties (EMP) of adult mouse dorsal root ganglion (DRG) neurons. These results in combination with results from additional experiments involving chronic exposure to hyposomotic medium provided furthe...

journal_title：Neurotoxicology

authors： Scott B,Lew J

更新日期：1986-04-01 00:00:00

abstract：:Bismuth levels in blood and brain of rats have been measured following acute or subchronic administration of tri-potassium-dicitrato bismuthate (TDB) by intraperitoneal injection or by gavage. After parenteral administration, the presence of bismuth in blood was associated with appreciable bismuth concentrations in br...

journal_title：Neurotoxicology

authors： Abbracchio MP,Balduini W,Cavallaro A,Adamoli P,Fittipaldi M,Muzio F,Malandrino S,Cattabeni F

更新日期：1985-10-01 00:00:00

abstract：:Skeletal muscle and peripheral nerve of mice exposed to subacute doses of chlordecone were examined by electron microscopy to characterize the induced pathology. Adult mice were given daily ip doses of chlordecone for 8 days, then sacrificed on days 8, 15, and 35 of the experiment. Sciatic nerve and gluteal muscle wer...

journal_title：Neurotoxicology

authors： Phillips DE,Eroschenko VP

更新日期：1985-04-01 00:00:00

abstract：:Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelin...

journal_title：Neurotoxicology

authors： Ehrich M,Jortner BS,Gross WB

更新日期：1985-04-01 00:00:00

abstract：:beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...

journal_title：Neurotoxicology

authors： Lowndes HE,Delio DA,Gold BG

更新日期：1985-01-01 00:00:00

abstract：:Studies on the toxicokinetics and biochemical effects of acrylamide are reviewed in regard to their implications concerning the mechanism of acrylamide induced neuropathy. Specifically, investigations of the effects of acrylamide on several glycolytic enzymes including neuron-specific enolase and glyceraldehyde-3-phos...

journal_title：Neurotoxicology

authors： Howland RD

更新日期：1985-01-01 00:00:00

abstract：:The time dependent tissue/organ distribution of Pb resulting from repeated intragastric exposure of the preweanling rat to Pb acetate was investigated. On the day of parturition, 12 dams were assigned randomly either to control (nonhandled) or Pb-treated groups and their litters were culled to 8 pups. On days 6, 9, 12...

journal_title：Neurotoxicology

authors： Massaro EJ,Miller GD,Massaro TF

更新日期：1984-10-01 00:00:00